TESK1

Across TCGA cell cohorts, TESK1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TESK1-associated genes across cancer lineages are WFDC12, DEFB4A, and BPIFA1. Each is linked with TESK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TESK1-to-partner and partner-to-TESK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC12 grouped by TESK1-low versus TESK1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TESK1→partner) and Y-score (partner→TESK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WFDC12 →	+0.163	+3.289	<.001	.009	3	1
BLOOD_Leukemia	DEFB4A →	+0.078	+3.684	.005	.004	3	1
BLOOD_Leukemia	BPIFA1 →	+0.065	+3.450	.003	.004	3	1
BLOOD_Leukemia	FAM24A →	+0.040	+3.969	<.001	.009	3	1
BLOOD_Leukemia	KRTAP5-11 →	+0.017	+3.289	.001	.009	3	1
BLOOD_Leukemia	USP17L11 →	+0.014	+3.684	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

WFDC12 by TESK1 expression — BLOOD_Leukemia

Explore this box plot interactively →