TERT

Across TCGA pan-cancer cohorts, TERT Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TERT data layer compared with 26 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher TERT Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TERT expression acts as an unfavorable survival marker.

THCA, PRAD, and SCLC are the cancer types where TERT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.294	0.945	<.001	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SCLC	OS	Median	All	0.219	0.706	.011	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	DFS	Median	All	0.223	0.691	.011	6	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	6	view →
SKCM	OS	Median	All	0.081	0.394	.006	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TERT–THCA (OS)

Open the THCA breakdown →