TERT

Across TCGA patient cohorts, TERT mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TERT-associated genes across cancer lineages are TIGAR, ATM, and NF2. Each is linked with TERT in more than 2 cancer types. Because this analysis shows association rather than direction, both TERT-to-partner and partner-to-TERT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by TERT-low versus TERT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TERT→partner) and Y-score (partner→TERT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.137	+1.611	.012	.011	3	3
UCEC	ATM →	-0.321	-1.986	.049	.029	3	3
UCEC	NF2 →	+0.195	+1.700	.012	.040	3	2
UCEC	p90 RSK →	+0.163	+2.125	.018	.010	3	2
SKCM	14-3-3_epsilon →	+0.162	+2.717	.002	.003	3	1
SKCM	SCD →	+0.139	+3.000	.034	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

TIGAR by TERT expression — UCEC

Explore this box plot interactively →