TERT

Across TCGA cell cohorts, TERT mutation is significantly associated with the RNA expression of many other genes, with 195 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TERT-associated genes across cancer lineages are LCN9, SNTG2, and OR1L3. Each is linked with TERT in more than 1 cancer types. Because this analysis shows association rather than direction, both TERT-to-partner and partner-to-TERT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCN9 grouped by TERT-low versus TERT-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TERT→partner) and Y-score (partner→TERT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LCN9 →	+0.079	+5.169	<.001	.005	3	2
BLOOD_Leukemia	SNTG2 →	+0.994	+3.491	.001	.009	3	2
BREAST	OR1L3 →	+0.019	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1
LUNG_SCLC	ADAM18 →	+0.030	+4.269	.004	.005	3	1
SKIN	ODF1 →	+0.013	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 195 associations by consensus.

LCN9 by TERT expression — BREAST

Explore this box plot interactively →