TERF2IP

Across TCGA pan-cancer cohorts, TERF2IP mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TERF2IP’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TERF2IP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TERF2IP is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LSCC, CCRCC, and LUAD are the cancer types where TERF2IP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TERF2IP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+0.275	<.001	8	view →
CCRCC	Male	III,IV	+0.170	<.001	7	view →
LUAD	Male	All	+0.155	<.001	7	view →
HNSC	Male	All	+0.151	<.001	6	view →
COAD	Male	All	+0.185	<.001	5	view →
PDAC	All	IV	−0.677	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TERF2IP–LSCC

Open the LSCC breakdown →