TERF2

Across TCGA patient cohorts, TERF2 mutation is significantly associated with the RNA expression of many other genes, with 492 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TERF2-associated genes across cancer lineages are RNA5SP319, MIR6133, and RNU6-800P. Each is linked with TERF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TERF2-to-partner and partner-to-TERF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP319 grouped by TERF2-low versus TERF2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TERF2→partner) and Y-score (partner→TERF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP319 →	+0.406	+5.097	<.001	.008	3	2
UCEC	MIR6133 →	+0.488	+2.661	<.001	.006	3	2
READ	RNU6-800P →	+0.415	+5.039	<.001	.008	3	2
READ	ANKRD33B-AS1 →	+0.187	+6.681	<.001	<.001	3	2
UCEC	IGHD3-9 →	+1.673	+2.383	<.001	.002	3	2
UCEC	IGHD1-1 →	+0.499	+3.461	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 492 associations by consensus.

RNA5SP319 by TERF2 expression — SKCM

Explore this box plot interactively →