TERF2

Across TCGA cell cohorts, TERF2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TERF2-associated genes across cancer lineages are CRISP1 and IQCF6. Each is linked with TERF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TERF2-to-partner and partner-to-TERF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRISP1 grouped by TERF2-low versus TERF2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TERF2→partner) and Y-score (partner→TERF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRISP1 →	+0.121	+5.201	.003	.006	3	1
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CRISP1 by TERF2 expression — BLOOD_Leukemia

Explore this box plot interactively →