Across TCGA pan-cancer cohorts, TERF1P3 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TERF1P3’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where TERF1P3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TERF1P3 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.
ESCA, LUAD, and STAD are the cancer types where TERF1P3 tumor–normal differential expression is most reproducible.