TERF1

Across TCGA pan-cancer cohorts, TERF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TERF1 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TERF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TERF1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, LSCC, and GBM are the cancer types where TERF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.322	0.842	.005	52	view →
LSCC	DFS	Median	II,III,IV	0.877	0.676	.014	22	view →
GBM	OS	Median	All	0.515	0.260	<.001	18	view →
HNSC	DFS	Median	III,IV	0.908	1.000	.011	7	view →
PDAC	OS	Quartile	II,III,IV	1.000	0.763	.006	6	view →
UCEC	OS	Quartile	All	1.000	0.840	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TERF1–CCRCC (OS)

Open the CCRCC breakdown →