TERF1

Across TCGA patient cohorts, TERF1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TERF1-associated genes across cancer lineages are 14-3-3_beta, ER-alpha_pS118, and PRAS40_pT246. Each is linked with TERF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TERF1-to-partner and partner-to-TERF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TERF1-low versus TERF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TERF1→partner) and Y-score (partner→TERF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.161	-3.156	.003	.020	3	1
UCEC	ER-alpha_pS118 →	-0.397	-3.169	.044	.020	3	1
UCEC	PRAS40_pT246 →	+0.213	+3.183	.023	.010	3	1
UCEC	N-Ras →	-0.156	-2.980	.017	.036	2	1
UCEC	MEK1 →	+0.522	+3.169	.009	.020	1	1
UCEC	Cyclin-B1 →	+0.630	+3.169	.041	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

14-3-3_beta by TERF1 expression — UCEC

Explore this box plot interactively →