TERF1

Across TCGA cell cohorts, TERF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,680 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TERF1-associated GO terms across cancer lineages are Regulation of establishment of protein localization to chromosome, Regulation of establishment of protein localization to telomere, and DNA biosynthetic process. Each is linked with TERF1 in more than 17 cancer types. Because this analysis shows association rather than direction, both TERF1-to-partner and partner-to-TERF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of establishment of protein localization to chromosome grouped by TERF1-low versus TERF1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TERF1→partner) and Y-score (partner→TERF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of establishment of protein localization to chromosome →	+0.179	+1.090	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Regulation of establishment of protein localization to telomere →	+0.149	+0.897	<.001	<.001	2	16
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.063	+0.750	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of protein localization to centrosome →	+0.163	+1.184	.007	.007	3	12
URINARY_TRACT	Telomere maintenance via telomerase →	+0.109	+0.751	<.001	<.001	3	12
BLOOD_Myeloma	Regulation of telomeric D-loop disassembly →	+0.122	+1.174	.004	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,680 associations by consensus.

Regulation of establishment of protein localization to chromosome by TERF1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →