TERC

Across TCGA pan-cancer cohorts, TERC RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TERC data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TERC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TERC expression acts as an unfavorable survival marker, although some lineages such as BLCA and THYM show a favorable association.

ESCA, BLCA, and KIRP are the cancer types where TERC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Quartile	III,IV	0.353	0.815	<.001	64	view →
BLCA	OS	Median	All	0.767	0.653	.003	58	view →
KIRP	DFS	Tertile	All	0.576	0.758	<.001	50	view →
UCEC	DFS	Quartile	All	0.846	0.935	<.001	36	view →
SKCM	DFS	Quartile	II,III,IV	0.472	0.616	.008	24	view →
THYM	OS	Quartile	II,III,IV	0.935	0.499	.009	24	view →
THCA	OS	Median	II,III,IV	0.561	1.000	.005	23	view →
CESC	OS	Tertile	IV	0.057	0.488	.011	18	view →
BRCA	DFS	Median	III,IV	0.653	0.398	.004	16	view →
STAD	OS	Median	IV	0.511	0.176	.005	15	view →
KICH	OS	Quartile	III,IV	0.204	0.768	.013	14	view →
COAD	DFS	Quartile	All	0.302	0.601	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TERC–ESCA (OS)

Open the ESCA breakdown →