TERB2

Across TCGA patient cohorts, TERB2 mutation is significantly associated with the RNA expression of many other genes, with 311 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TERB2-associated genes across cancer lineages are AGGF1P5, VWA1, and TPT1P10. Each is linked with TERB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TERB2-to-partner and partner-to-TERB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGGF1P5 grouped by TERB2-low versus TERB2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TERB2→partner) and Y-score (partner→TERB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AGGF1P5 →	+0.019	+4.039	<.001	.009	3	2
UCEC	VWA1 →	-0.949	-3.448	.001	.005	3	1
UCEC	TPT1P10 →	+0.323	+3.721	.001	.002	3	1
UCEC	HSP90AA6P →	+0.844	+3.470	<.001	.003	3	1
UCEC	ALG12 →	+0.795	+3.491	.006	.002	3	1
UCEC	TSPYL2 →	+0.665	+3.480	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 311 associations by consensus.

AGGF1P5 by TERB2 expression — SKCM

Explore this box plot interactively →