TEPSIN

Across TCGA patient cohorts, TEPSIN mutation is significantly associated with the RNA expression of many other genes, with 1,288 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEPSIN-associated genes across cancer lineages are PGAM1, MIR4497, and DUX4L46. Each is linked with TEPSIN in more than 2 cancer types. Because this analysis shows association rather than direction, both TEPSIN-to-partner and partner-to-TEPSIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAM1 grouped by TEPSIN-low versus TEPSIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEPSIN→partner) and Y-score (partner→TEPSIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAM1 →	+0.555	+1.925	.007	.004	3	3
SKCM	MIR4497 →	+0.441	+2.678	<.001	.007	3	3
LUSC	DUX4L46 →	+0.109	+4.651	<.001	.001	3	2
CESC	SMIM28 →	+0.108	+3.069	<.001	.002	3	2
CESC	RPS28P8 →	+0.054	+4.777	<.001	.002	3	2
COAD	RNA5SP477 →	+0.597	+3.009	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,288 associations by consensus.

PGAM1 by TEPSIN expression — UCEC

Explore this box plot interactively →