TEPSIN

Across TCGA patient cohorts, TEPSIN mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEPSIN-associated genes across cancer lineages are eEF2, MSH6, and mTOR_pS2448. Each is linked with TEPSIN in more than 1 cancer types. Because this analysis shows association rather than direction, both TEPSIN-to-partner and partner-to-TEPSIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TEPSIN-low versus TEPSIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEPSIN→partner) and Y-score (partner→TEPSIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.321	+3.321	.010	.009	3	2
UCEC	MSH6 →	-0.371	-3.459	.001	.005	3	2
UCEC	mTOR_pS2448 →	-0.129	-1.362	.014	.037	3	2
UCEC	p27_pT198 →	+0.106	+3.169	.005	.018	3	2
UCEC	PRAS40_pT246 →	+0.155	+1.375	.010	.024	3	2
UCEC	STAT3_pY705 →	-0.311	-2.690	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eEF2 by TEPSIN expression — UCEC

Explore this box plot interactively →