TEPSIN

Across TCGA cell cohorts, TEPSIN mutation is significantly associated with the mutation status of many other genes, with 774 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TEPSIN-associated genes across cancer lineages are OPLAH, PFKP, and PAPLN. Each is linked with TEPSIN in more than 2 cancer types. Because this analysis shows association rather than direction, both TEPSIN-to-partner and partner-to-TEPSIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPLAH grouped by TEPSIN-low versus TEPSIN-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEPSIN→partner) and Y-score (partner→TEPSIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OPLAH →	+5.014	+5.584	.003	.003	1	3
SOFT_TISSUE	PFKP →	+5.066	+4.502	.007	.007	1	3
LUNG_NSCLC_LUAD	PAPLN →	+4.339	+4.339	.009	.009	1	2
LUNG_NSCLC_LUAD	COL20A1 →	+2.924	+4.334	.006	.006	1	2
LUNG_NSCLC_LUAD	CHRNA4 →	+4.339	+4.339	.009	.009	1	2
LUNG_NSCLC_LUAD	GRM6 →	+2.754	+4.189	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 774 associations by consensus.

OPLAH by TEPSIN expression — BLOOD_Lymphoma

Explore this box plot interactively →