TENT5D

Across TCGA pan-cancer cohorts, TENT5D Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TENT5D data layer compared with 16 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TENT5D Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TENT5D expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

HNSC, UCEC, and COAD are the cancer types where TENT5D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.155	0.758	<.001	39	view →
UCEC	OS	Median	II,III,IV	0.951	0.494	.006	34	view →
COAD	OS	Median	III,IV	0.112	0.800	<.001	15	view →
SKCM	OS	Median	All	0.107	0.329	.003	12	view →
SARC	DFS	Median	All	0.172	0.612	.015	6	view →
LIHC	DFS	Median	II,III,IV	0.100	0.419	.012	3	view →
LUAD	OS	Median	All	0.845	0.336	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TENT5D–HNSC (OS)

Open the HNSC breakdown →