TENT5A

Across TCGA pan-cancer cohorts, TENT5A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TENT5A data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TENT5A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TENT5A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SCLC, HNSC, and UCEC are the cancer types where TENT5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.082	0.564	.002	30	view →
HNSC	DFS	Median	III,IV	0.161	0.680	.016	24	view →
UCEC	DFS	Median	All	0.942	0.623	.016	20	view →
SARC	OS	Median	All	0.164	0.827	<.001	6	view →
LGG	OS	Median	All	0.214	0.889	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TENT5A–SCLC (DFS)

Open the SCLC breakdown →