TENT5A

Across TCGA pan-cancer cohorts, TENT5A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TENT5A data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TENT5A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TENT5A expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where TENT5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.363	1.000	<.001	22	view →
LUAD	DFS	Median	All	0.723	0.471	.049	2	view →
PDAC	DFS	Median	All	0.508	0.292	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TENT5A–LSCC (DFS)

Open the LSCC breakdown →