TENT4B

Across TCGA pan-cancer cohorts, TENT4B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TENT4B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TENT4B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TENT4B is over-expressed in tumor, although a few such as OV and PDAC show the opposite, repressed pattern.

COAD, LSCC, and LUAD are the cancer types where TENT4B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TENT4B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.362	.002	7	view →
LSCC	All	II,III,IV	+0.233	<.001	7	view →
LUAD	Male	All	+0.182	<.001	6	view →
OV	All	All	−0.880	.024	2	view →
PDAC	All	All	−0.219	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TENT4B–COAD

Open the COAD breakdown →