TENT2

Across TCGA pan-cancer cohorts, TENT2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TENT2 data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TENT2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TENT2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, KIRC, and BLCA are the cancer types where TENT2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.130	0.703	<.001	24	view →
KIRC	OS	Median	All	0.167	0.630	.008	12	view →
BLCA	OS	Median	IV	0.145	0.604	<.001	12	view →
BRCA	OS	Median	All	0.175	0.579	.042	4	view →
UCEC	DFS	Median	All	0.912	0.615	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TENT2–ESCA (OS)

Open the ESCA breakdown →