TENT2

Across TCGA patient cohorts, TENT2 mutation is significantly associated with the RNA expression of many other genes, with 2,524 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENT2-associated genes across cancer lineages are RNA5SP435, HMGB1P7, and RNA5SP68. Each is linked with TENT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TENT2-to-partner and partner-to-TENT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP435 grouped by TENT2-low versus TENT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENT2→partner) and Y-score (partner→TENT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP435 →	+0.454	+1.407	<.001	.008	3	2
READ	HMGB1P7 →	+0.131	+4.202	.001	.008	3	2
SKCM	RNA5SP68 →	+0.226	+4.282	<.001	.009	3	2
READ	PGBD4P2 →	+0.121	+5.257	<.001	.002	3	1
UCEC	FAM219B →	+0.445	+1.938	<.001	.001	3	1
UCEC	RIIAD1 →	-0.923	-2.622	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,524 associations by consensus.

RNA5SP435 by TENT2 expression — UCEC

Explore this box plot interactively →