TENT2

Across TCGA cell cohorts, TENT2 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TENT2-associated genes across cancer lineages are OR52W1, TRIM51, and ZNF479. Each is linked with TENT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TENT2-to-partner and partner-to-TENT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52W1 grouped by TENT2-low versus TENT2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENT2→partner) and Y-score (partner→TENT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR52W1 →	+0.048	+3.514	<.001	.008	2	3
PANCREAS	TRIM51 →	+0.025	+4.614	<.001	.004	3	1
PANCREAS	ZNF479 →	+0.019	+5.139	<.001	<.001	3	1
BREAST	SEMG1 →	+0.152	+4.421	<.001	.004	3	1
LUNG_NSCLC_LUAD	SIGLEC7 →	+0.040	+4.215	.002	.002	3	1
BLOOD_Leukemia	MEDAG →	+0.086	+3.217	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

OR52W1 by TENT2 expression — BLOOD_Leukemia

Explore this box plot interactively →