Across TCGA pan-cancer cohorts, TENM3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TENM3 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TENM3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TENM3 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where TENM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.289	0.549	.001	24	view →
LSCC	DFS	Quartile	II,III,IV	0.540	0.925	.009	8	view →
HNSC	DFS	Median	III,IV	1.000	0.929	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TENM3 tumor-vs-normal RNA expression · all TENM3 data types