Across TCGA pan-cancer cohorts, TENM3 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of TENM3’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where TENM3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TENM3 is over-expressed in tumor.

PDAC and LSCC are the cancer types where TENM3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TENM3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	+0.425	.004	3	view →
LSCC	All	All	+0.234	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TENM3 RNA expression & survival · all TENM3 data types