Across TCGA patient cohorts, TENM3 mutation is significantly associated with the RNA expression of many other genes, with 11,068 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENM3-associated genes across cancer lineages are KIF2C, MRPS15, and MND1. Each is linked with TENM3 in more than 7 cancer types. Because this analysis shows association rather than direction, both TENM3-to-partner and partner-to-TENM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENM3→partner) and Y-score (partner→TENM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIF2C →	+0.873	+1.547	<.001	.001	3	8
STAD	MRPS15 →	+0.388	+2.263	<.001	<.001	3	8
STAD	MND1 →	+0.791	+3.132	<.001	<.001	3	8
READ	EBNA1BP2 →	+0.447	+3.197	.008	.007	3	7
BRCA	EXO1 →	+0.927	+3.584	.004	.003	3	7
COAD	TYMS →	+0.907	+2.624	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,068 associations by consensus.

Exploration

TENM3 survival (RNA) · tumor vs normal (RNA) · all TENM3 data types