Across TCGA patient cohorts, TENM3 mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENM3-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and FoxM1. Each is linked with TENM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both TENM3-to-partner and partner-to-TENM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENM3→partner) and Y-score (partner→TENM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+0.515	+1.584	.002	.018	3	5
COAD	Caspase-7-cleavedD198 →	+1.137	+3.264	<.001	<.001	3	5
LUAD	FoxM1 →	+0.268	+1.498	.002	.032	3	4
COAD	ATM →	-0.372	-1.678	<.001	.018	3	4
LUAD	PDCD4 →	-0.333	-1.568	.021	.018	3	4
UCEC	4E-BP1 →	+0.242	+1.212	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

Exploration

TENM3 survival (RNA) · tumor vs normal (RNA) · all TENM3 data types