Across TCGA cell cohorts, TENM3 mutation is significantly associated with the RNA expression of many other genes, with 1,488 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TENM3-associated genes across cancer lineages are GID4, NPIPB11, and MYG1. Each is linked with TENM3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TENM3-to-partner and partner-to-TENM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENM3→partner) and Y-score (partner→TENM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GID4 →	+0.430	+1.714	.003	.001	3	4
LUNG_NSCLC_LUAD	NPIPB11 →	+0.306	+3.137	.009	.007	3	3
BLOOD_Leukemia	MYG1 →	+0.401	+3.290	.004	.003	3	3
LARGE_INTESTINE	THAP3 →	+0.467	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	PIGL →	+0.697	+3.700	<.001	<.001	3	3
LARGE_INTESTINE	RPRD1A →	+0.641	+2.700	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,488 associations by consensus.

Exploration

TENM3 survival (RNA) · tumor vs normal (RNA) · all TENM3 data types