TENM1

Across TCGA patient cohorts, TENM1 mutation is significantly associated with the RNA expression of many other genes, with 10,620 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENM1-associated genes across cancer lineages are FHL1, PDZD2, and MMS22L. Each is linked with TENM1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TENM1-to-partner and partner-to-TENM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FHL1 grouped by TENM1-low versus TENM1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENM1→partner) and Y-score (partner→TENM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FHL1 →	-0.660	-2.050	<.001	<.001	3	6
STAD	PDZD2 →	-0.599	-2.502	<.001	.001	3	6
UCEC	MMS22L →	+0.211	+1.088	.003	.002	3	6
UCEC	SRPX →	-0.523	-1.048	<.001	<.001	3	5
UCEC	NCAPG →	+0.524	+1.152	<.001	<.001	3	5
LUAD	AUNIP →	+0.465	+1.722	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,620 associations by consensus.

FHL1 by TENM1 expression — LUAD

Explore this box plot interactively →