TEKT5

Across TCGA patient cohorts, TEKT5 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEKT5-associated genes across cancer lineages are JNK2, N-Ras, and beta-Catenin. Each is linked with TEKT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEKT5-to-partner and partner-to-TEKT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TEKT5-low versus TEKT5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEKT5→partner) and Y-score (partner→TEKT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	JNK2 →	+0.209	+1.891	.027	.030	3	2
SKCM	N-Ras →	-0.151	-3.459	.016	.005	3	2
SKCM	beta-Catenin →	+0.561	+3.000	.019	.035	3	2
SKCM	C-Raf →	+0.187	+2.824	.003	.034	3	2
UCEC	MSH2 →	-0.204	-2.433	.016	.018	3	2
UCEC	mTOR_pS2448 →	-0.140	-1.502	.010	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

JNK2 by TEKT5 expression — SKCM

Explore this box plot interactively →