TEKT2

Across TCGA patient cohorts, TEKT2 mutation is significantly associated with the RNA expression of many other genes, with 556 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEKT2-associated genes across cancer lineages are RNU6-993P, GCSHP2, and RNA5SP411. Each is linked with TEKT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEKT2-to-partner and partner-to-TEKT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-993P grouped by TEKT2-low versus TEKT2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEKT2→partner) and Y-score (partner→TEKT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-993P →	+0.362	+5.259	.001	.007	3	2
BRCA	GCSHP2 →	+0.117	+5.122	<.001	.008	3	2
UCEC	RNA5SP411 →	+1.476	+2.393	<.001	.001	3	2
UCEC	OSGIN1 →	+1.326	+3.606	<.001	.001	3	2
SKCM	MTND4P33 →	+0.018	+3.993	<.001	.008	3	2
UCEC	RNU6-1082P →	+0.409	+3.414	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 556 associations by consensus.

RNU6-993P by TEKT2 expression — BRCA

Explore this box plot interactively →