TEKT2

Across TCGA patient cohorts, TEKT2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEKT2-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and p70-S6K. Each is linked with TEKT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEKT2-to-partner and partner-to-TEKT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TEKT2-low versus TEKT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEKT2→partner) and Y-score (partner→TEKT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.299	-2.459	.013	.020	3	2
UCEC	A-Raf_pS299 →	-0.128	-3.000	.027	.036	3	1
UCEC	p70-S6K →	+0.190	+2.486	.041	.011	3	1
UCEC	PCNA →	+0.294	+2.459	.004	.020	3	1
UCEC	Raptor →	-0.182	-2.459	.013	.020	3	1
UCEC	Annexin-1 →	+0.544	+2.827	.032	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by TEKT2 expression — UCEC

Explore this box plot interactively →