TEKT2

Across TCGA cell cohorts, TEKT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,780 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TEKT2-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, Spliceosomal complex assembly, and Positive regulation of transcription elongation by RNA polymerase II. Each is linked with TEKT2 in more than 8 cancer types. Because this analysis shows association rather than direction, both TEKT2-to-partner and partner-to-TEKT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by TEKT2-low versus TEKT2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TEKT2→partner) and Y-score (partner→TEKT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of mRNA splicing, via spliceosome →	+0.086	+0.222	<.001	.009	3	9
LUNG_SCLC	Spliceosomal complex assembly →	+0.077	+1.601	.001	<.001	3	9
LUNG_SCLC	Positive regulation of transcription elongation by RNA polymerase II →	+0.061	+1.641	.001	<.001	3	9
SOFT_TISSUE	Regulation of RNA splicing →	+0.049	+0.185	.001	.004	3	9
BONE	Establishment of RNA localization →	+0.106	+1.616	<.001	.001	3	9
BONE	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.133	+1.896	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,780 associations by consensus.

Regulation of mRNA splicing, via spliceosome by TEKT2 expression — SOFT_TISSUE

Explore this box plot interactively →