TEKT1

Across TCGA patient cohorts, TEKT1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEKT1-associated genes across cancer lineages are PKC-b-II_pS660, eEF2, and ERK2. Each is linked with TEKT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TEKT1-to-partner and partner-to-TEKT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by TEKT1-low versus TEKT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEKT1→partner) and Y-score (partner→TEKT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.286	-2.321	.003	.005	3	3
UCEC	eEF2 →	+0.412	+2.807	.001	.002	3	2
UCEC	ERK2 →	+0.262	+2.000	<.001	.003	3	2
UCEC	GAPDH →	+0.460	+2.584	.015	.010	3	2
UCEC	ASNS →	+0.338	+1.700	.008	.042	3	2
UCEC	Bax →	+0.246	+2.000	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

PKC-b-II_pS660 by TEKT1 expression — UCEC

Explore this box plot interactively →