TEFM

Across TCGA pan-cancer cohorts, TEFM mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TEFM’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where TEFM mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TEFM is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, COAD, and LSCC are the cancer types where TEFM tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TEFM mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−0.906	<.001	12	view →
COAD	Male	II,III,IV	+0.477	<.001	10	view →
LSCC	All	III,IV	+0.445	<.001	8	view →
PDAC	Male	All	−0.939	<.001	6	view →
LUAD	All	II,III,IV	+0.256	<.001	6	view →
HNSC	All	All	+0.174	.021	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TEFM–CCRCC

Open the CCRCC breakdown →