TEFM

Across TCGA patient cohorts, TEFM mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEFM-associated genes across cancer lineages are Notch1, p62 Lck ligand, and Cyclin-B1. Each is linked with TEFM in more than 1 cancer types. Because this analysis shows association rather than direction, both TEFM-to-partner and partner-to-TEFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TEFM-low versus TEFM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEFM→partner) and Y-score (partner→TEFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.259	+3.169	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.408	+3.331	.001	.005	3	2
UCEC	Cyclin-B1 →	+0.861	+3.169	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.262	-2.502	.007	.002	3	1
UCEC	eIF4G →	+0.316	+1.584	.009	.036	3	1
UCEC	A-Raf_pS299 →	-0.119	-2.584	.010	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Notch1 by TEFM expression — UCEC

Explore this box plot interactively →