TEFM

Across TCGA cell cohorts, TEFM RNA expression is significantly associated with the go_rna of many other GO terms, with 3,068 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TEFM-associated GO terms across cancer lineages are Regulation of mitochondrial gene expression, Regulation of mitochondrial transcription, and Protein localization to chromosome, centromeric region. Each is linked with TEFM in more than 17 cancer types. Because this analysis shows association rather than direction, both TEFM-to-partner and partner-to-TEFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitochondrial gene expression grouped by TEFM-low versus TEFM-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TEFM→partner) and Y-score (partner→TEFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of mitochondrial gene expression →	+0.115	+0.669	<.001	.001	3	18
KIDNEY	Regulation of mitochondrial transcription →	+0.141	+0.751	<.001	<.001	3	15
SOFT_TISSUE	Protein localization to chromosome, centromeric region →	+0.076	+0.476	.001	<.001	3	15
SOFT_TISSUE	Mitochondrial gene expression →	+0.076	+0.658	<.001	<.001	3	14
BLOOD_Myeloma	Somatic recombination of immunoglobulin gene segments →	+0.064	+0.801	.001	<.001	3	12
LUNG_SCLC	Protein localization to condensed chromosome →	+0.135	+0.537	.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,068 associations by consensus.

Regulation of mitochondrial gene expression by TEFM expression — LUNG_SCLC

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