TEDC2

Across TCGA patient cohorts, TEDC2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEDC2-associated genes across cancer lineages are eIF4G, FoxM1, and INPP4B. Each is linked with TEDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEDC2-to-partner and partner-to-TEDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by TEDC2-low versus TEDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEDC2→partner) and Y-score (partner→TEDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.406	+3.321	.009	.010	3	1
UCEC	FoxM1 →	+0.359	+3.459	.005	.005	3	1
UCEC	INPP4B →	-0.359	-2.999	.027	.035	3	1
UCEC	JNK2 →	+0.323	+3.009	.001	.019	3	1
UCEC	mTOR_pS2448 →	-0.191	-2.321	.010	.035	3	1
UCEC	p21 →	+0.215	+2.820	.025	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4G by TEDC2 expression — UCEC

Explore this box plot interactively →