TECTB

Across TCGA patient cohorts, TECTB mutation is significantly associated with the RNA expression of many other genes, with 1,314 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TECTB-associated genes across cancer lineages are SNRPCP6, TCP11X3P, and ARPP19P2. Each is linked with TECTB in more than 2 cancer types. Because this analysis shows association rather than direction, both TECTB-to-partner and partner-to-TECTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPCP6 grouped by TECTB-low versus TECTB-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TECTB→partner) and Y-score (partner→TECTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SNRPCP6 →	+0.526	+4.425	<.001	.006	3	3
UCEC	TCP11X3P →	+0.442	+4.354	<.001	<.001	3	3
HNSC	ARPP19P2 →	+0.139	+4.425	.002	.006	3	2
HNSC	PRELID1P2 →	+0.091	+5.339	.001	.003	3	2
HNSC	LUZP4P1 →	+0.393	+5.063	<.001	.001	3	2
HNSC	C3orf85 →	+0.479	+4.813	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,314 associations by consensus.

SNRPCP6 by TECTB expression — HNSC

Explore this box plot interactively →