TECTB

Across TCGA patient cohorts, TECTB mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TECTB-associated genes across cancer lineages are TFRC, Gab2, and INPP4B. Each is linked with TECTB in more than 1 cancer types. Because this analysis shows association rather than direction, both TECTB-to-partner and partner-to-TECTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by TECTB-low versus TECTB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TECTB→partner) and Y-score (partner→TECTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TFRC →	+0.734	+3.000	.021	.036	3	2
UCEC	Gab2 →	+0.531	+2.459	.002	.020	3	1
UCEC	INPP4B →	-0.324	-3.321	.038	.009	3	1
UCEC	Ku80 →	+0.290	+2.472	.011	.011	3	1
UCEC	p62 Lck ligand →	+0.391	+2.459	.012	.020	3	1
UCEC	PCNA →	+0.291	+3.000	.005	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

TFRC by TECTB expression — SKCM

Explore this box plot interactively →