TECTA

Across TCGA patient cohorts, TECTA mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TECTA-associated genes across cancer lineages are Caveolin-1, 4E-BP1, and FOXO3a_pS318_S321. Each is linked with TECTA in more than 5 cancer types. Because this analysis shows association rather than direction, both TECTA-to-partner and partner-to-TECTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by TECTA-low versus TECTA-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TECTA→partner) and Y-score (partner→TECTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caveolin-1 →	-0.623	-1.807	.026	.025	3	6
READ	4E-BP1 →	+0.316	+3.169	.005	.016	3	5
BLCA	FOXO3a_pS318_S321 →	-0.167	-3.169	.019	.019	3	4
COAD	Caspase-7-cleavedD198 →	+0.606	+1.782	.004	.006	3	4
UCEC	STAT3_pY705 →	-0.315	-1.530	<.001	<.001	3	4
UCEC	ATM →	-0.604	-1.966	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

Caveolin-1 by TECTA expression — STAD

Explore this box plot interactively →