TECTA

Across TCGA cell cohorts, TECTA mutation is significantly associated with the RNA expression of many other genes, with 937 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TECTA-associated genes across cancer lineages are C17orf58, FBXO25, and H2AZ1. Each is linked with TECTA in more than 3 cancer types. Because this analysis shows association rather than direction, both TECTA-to-partner and partner-to-TECTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C17orf58 grouped by TECTA-low versus TECTA-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TECTA→partner) and Y-score (partner→TECTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C17orf58 →	+0.773	+3.358	.002	.003	3	3
BLOOD_Leukemia	FBXO25 →	+0.985	+3.199	.007	.007	3	3
LARGE_INTESTINE	H2AZ1 →	+0.428	+1.290	.006	.006	2	4
PANCREAS	C6 →	+0.434	+3.781	<.001	.003	3	2
SKIN	LEKR1 →	-0.554	-3.416	.003	.002	3	2
OVARY	ASPA →	+0.052	+2.358	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 937 associations by consensus.

C17orf58 by TECTA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →