Across TCGA pan-cancer cohorts, TEAD4 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TEAD4 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TEAD4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TEAD4 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC and HNSC are the cancer types where TEAD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	1.000	0.689	.007	17	view →
HNSC	DFS	Median	II,III,IV	0.657	0.900	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TEAD4 tumor-vs-normal RNA expression · all TEAD4 data types