Across TCGA patient cohorts, TEAD4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,384 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TEAD4-associated genes across cancer lineages are GINS1, MCM4, and RAD51AP1. Each is linked with TEAD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TEAD4-to-partner and partner-to-TEAD4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEAD4→partner) and Y-score (partner→TEAD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GINS1 →	+0.968	+0.543	<.001	.002	3	2
LSCC	MCM4 →	+1.094	+0.596	<.001	.001	3	2
BRCA	RAD51AP1 →	+1.207	+0.656	.007	.004	2	3
BRCA	CDCA3 →	+1.180	+0.651	.004	.002	2	3
LSCC	TMPO →	+0.785	+0.591	.002	.002	3	2
LSCC	CENPE →	+0.836	+0.489	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,384 associations by consensus.

Exploration

TEAD4 survival (RNA) · tumor vs normal (RNA) · all TEAD4 data types