Across TCGA patient cohorts, TEAD4 mutation is significantly associated with the RNA expression of many other genes, with 1,577 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEAD4-associated genes across cancer lineages are RPL12P39, MIR5688, and RDM1P2. Each is linked with TEAD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEAD4-to-partner and partner-to-TEAD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEAD4→partner) and Y-score (partner→TEAD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL12P39 →	+0.063	+2.592	<.001	.005	3	2
HNSC	MIR5688 →	+0.529	+5.368	<.001	.005	3	2
HNSC	RDM1P2 →	+0.086	+5.015	.001	.009	3	2
ESCA	LINC00280 →	+0.071	+4.681	<.001	.006	3	2
UCEC	TRAJ30 →	+0.390	+1.935	.001	.002	3	2
UCEC	RN7SL447P →	+0.104	+1.978	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,577 associations by consensus.

Exploration

TEAD4 survival (RNA) · tumor vs normal (RNA) · all TEAD4 data types