Across TCGA patient cohorts, TEAD4 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEAD4-associated genes across cancer lineages are GSK3-a-b, MEK1, and MSH2. Each is linked with TEAD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEAD4-to-partner and partner-to-TEAD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEAD4→partner) and Y-score (partner→TEAD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK3-a-b →	-0.124	-2.459	.019	.019	3	1
UCEC	MEK1 →	+0.444	+3.459	.001	.005	3	1
UCEC	MSH2 →	-0.401	-2.797	<.001	.003	3	1
UCEC	MSH6 →	-0.436	-3.459	<.001	.005	3	1
UCEC	Notch1 →	+0.143	+2.183	.009	.033	3	1
UCEC	p62 Lck ligand →	+0.344	+2.710	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

TEAD4 survival (RNA) · tumor vs normal (RNA) · all TEAD4 data types