TEAD3

Across TCGA patient cohorts, TEAD3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEAD3-associated genes across cancer lineages are eIF4E, MEK1, and p62 Lck ligand. Each is linked with TEAD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEAD3-to-partner and partner-to-TEAD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TEAD3-low versus TEAD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEAD3→partner) and Y-score (partner→TEAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.190	+2.321	.045	.034	3	1
UCEC	MEK1 →	+0.403	+2.999	.014	.035	3	1
UCEC	p62 Lck ligand →	+0.434	+2.179	.003	.034	3	1
UCEC	TIGAR →	+0.188	+3.833	.006	<.001	3	1
UCEC	4E-BP1 →	+0.394	+3.199	.001	.009	2	2
UCEC	DJ-1 →	+0.168	+3.169	.025	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eIF4E by TEAD3 expression — UCEC

Explore this box plot interactively →