TEAD2

Across TCGA cell cohorts, TEAD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,527 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TEAD2-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase I promoter, Regulation of lysosomal membrane permeability, and Protein-DNA complex organization. Each is linked with TEAD2 in more than 10 cancer types. Because this analysis shows association rather than direction, both TEAD2-to-partner and partner-to-TEAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase I promoter grouped by TEAD2-low versus TEAD2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TEAD2→partner) and Y-score (partner→TEAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Transcription initiation at RNA polymerase I promoter →	+0.083	+1.579	.004	<.001	3	11
LIVER	Regulation of lysosomal membrane permeability →	+0.212	+1.217	.001	.001	3	10
BONE	Protein-DNA complex organization →	+0.087	+2.191	<.001	<.001	3	10
BONE	Regulation of double-strand break repair via homologous recombination →	+0.106	+2.212	.001	<.001	3	9
PANCREAS	Nuclear transport →	+0.053	+1.342	<.001	<.001	3	9
OVARY	DNA-templated transcription elongation →	+0.078	+1.582	.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,527 associations by consensus.

Transcription initiation at RNA polymerase I promoter by TEAD2 expression — PANCREAS

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