TEAD2

Across TCGA cell cohorts, TEAD2 mutation is significantly associated with the RNA expression of many other genes, with 363 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TEAD2-associated genes across cancer lineages are ATG4C, KSR2, and MRPL42. Each is linked with TEAD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEAD2-to-partner and partner-to-TEAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATG4C grouped by TEAD2-low versus TEAD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEAD2→partner) and Y-score (partner→TEAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATG4C →	+0.485	+2.459	.001	.006	3	2
LARGE_INTESTINE	KSR2 →	+0.498	+2.265	<.001	.001	3	2
LARGE_INTESTINE	MRPL42 →	+0.558	+2.459	<.001	.006	3	2
LARGE_INTESTINE	ME2 →	+0.982	+3.169	<.001	.006	3	2
LARGE_INTESTINE	GCAT →	+0.980	+2.265	.004	.001	3	1
LARGE_INTESTINE	DDHD1 →	+0.774	+2.265	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

ATG4C by TEAD2 expression — LARGE_INTESTINE

Explore this box plot interactively →