Across TCGA pan-cancer cohorts, TEAD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TEAD1 data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TEAD1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TEAD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where TEAD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.955	0.759	.007	16	view →
LSCC	DFS	Median	III,IV	0.567	0.984	.024	15	view →
PDAC	OS	Median	IV	0.962	0.381	.017	7	view →
CCRCC	OS	Quartile	All	0.960	0.760	.029	7	view →
LUAD	OS	Tertile	II,III,IV	0.860	1.000	.032	3	view →
GBM	OS	Median	All	0.663	0.862	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: TEAD1 tumor-vs-normal RNA expression · all TEAD1 data types